抗环瓜氨酸肽抗体检测在类风湿关节炎中的诊断及预后意义探讨_周

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"本文编辑8张少然#

抗环瓜氨酸肽抗体检测在类风湿关节炎中的诊断及预后意义探讨

周彬

$摘

朱静

要%

刘建

目的

龙武彬吴晓丹程佳吴侗

评价抗环瓜氨酸肽"&&\#抗体和类风湿因子"+E#在鉴别类风湿关节炎"+X#和其

采用横断面研究&在P!V

他风湿性疾病中的意义&探讨+X骨侵蚀与上述两种抗体之间的相关性’方法

例+X&V$例其他风湿性疾病&VV例非风湿性疾病中检测上述两种抗体&其中抗&&\抗体采用酶联免疫吸附试验"YBTGX#法&TDS9+E采用速率比浊法’分析+X骨侵蚀与上述两种抗体之间的相关性’结果

TDS9

+E诊断+X的敏感性较抗&&\抗体高"+EV%:#^&抗&&\抗体V#:#^#"!_":VR#(但抗&&\抗体有更高的

诊断特异性"抗&&\抗体Q#:$^&TDS9+E%#:R^#"!_":"PV#&且两种检测方法之间无相关性’联合检测抗

&&\抗体和TDS9+E有很高的特异性Q%:!^&较单独检测TDS9+E有更高的阳性预测值"\\4#QV:R^"!_":"PQ#&阴性预测值"5\4#有下降VR:R^"!_":!P;#’抗&&\抗体阳性!TDS9+E阳性与+X骨侵蚀相关’结

论

抗&&\抗体与TDS9+E比较对+X有良好的诊断敏感性与特异性&可视为+X新的血清学诊断指标’)关键词%

关节炎&类风湿(

抗环瓜氨酸肽抗体(

类风湿因子(

骨疾病

抗&&\抗体与+X骨侵蚀的关系值得进一步研究’

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作者单位*"#$$%&成都&四川省人民医院风湿科

中华风湿病学杂志!""#年$月第%卷第$期&’()*+’,-./0123*-),!""#3412%3516$

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类风湿关节炎!7’,-./01(8/70’7(0(9"+:#是一种慢性$炎症性$多关节受累的系统性自身免疫性疾病"它可导致软骨和骨的破坏"从而导致永久的残疾%由于+:有致畸性"现代的治疗倾向于在疾 …… 此处隐藏：7697字，全部文档内容请下载后查看。喜欢就下载吧 ……