教学文库网 - 权威文档分享云平台
您的当前位置:首页 > 文库大全 > 资格考试 >

PTEN、VEGF和MMP2在胃癌组织中的表达及其与胃癌浸润、转移和预后(2)

来源:网络收集 时间:2026-03-23
导读: waspositivelycorrelatedwiththat ofMMP2.(5)The 3yearpostoperationsurvivalrateofpatientsWas significant

waspositivelycorrelatedwiththat

ofMMP2.(5)The

3yearpostoperationsurvivalrateofpatientsWas

significantlycorrelatedwithdepthof

窒整垦壁垄生塑主兰垒丝圭

一——

tumorinvasion,distantmetastasis

andtumorstaging,butthe

5yearpostoperation

survivalrateofpatientswassignificantlycorrelatedwithdepthofturnerinvasion,

lymph

node

metastasis,distantmetastasis

and

tumor

staging;The

3,5

year

postoperation

survival

rates

ofpatients

withhighly

expression

ofPTENwere

significantly

higherthanthosewithreducedexpressionofPTEN;The3,5yearpostoperationsurvivalratesofpatientswithpositivelyexpressionofVEGFandMMP2

were

significantly

lower

thanthosewithnegatively

expressionofVEGFand

MMP2;Kaplan—Meiersurvival

curves

alsoshowedthatthesurvivaltimeofpatientswith

hi曲ly

expressionofPTENweresignificantlylonger

thanthosewithreducedexpres.sionof

PTEN,Log—ranktest,P<O,05,butthesurvivaltimeofpatientswithpositivelyexpression

ofVEGFand

MMP2weresignificantlyshorterthanthosewimnegativelyexpression

of

VEGFandMMP2,Log—ranktest,P<0.01;Univariate

analysisusing

Coxproportional

hazardsmodelfoundthatprognosisofpatientswithgastriccarcinomawassignificantly

correlatedwithdepth

oftumor

invasion,lymph

node

metastasis,distantmetastasis,

tumorstaging

andexpressionofPTEN,VEGF

and

MMP2;Multivariateanalysisusing

Coxproportionalhazardsmodelfoundthatdepthoftumor

invasion,lymph

node

metastasis,tqlmorstaging

and

expressionofVEGFand

MMP2in

gastriccarcinoma

wereindependentriskfactors,bntexpressionofPTENwasnotindependentriskfactor.

Conclusion(1)Expression

ofPTENingastriccarcinomawassignificantlylower

than

thatinnormalgastrictissues

andreducedexpressionofPTENcouldhelpthediagnosis

ofgastriccarcinomaatearly

stage.佗)Expression

ofPTEN,VEGFandMMP2

significantly

correlatedwithclinicalandbiologicalfactors

andthey

were

important

factors

determining

molecularand

biological

features

of

gastric

carcinoma.

(3)ExpressionofPTENsignificantlycorrelatedwith

thatofVEGF

andMMP2.PTEN

couldsuppresstumorinvasionandmetastasisbymeans

ofregulatingtheexpressionof

VEGF

andMMP2.(4)Reducedexpression

ofPTENandhigblyexpressionofVEGF

andMMP2promotedtumorinvasionandmetastasisingastriccarcinoma.Detecting

塞垡堕壁垄主堡主主堡丝圭———————————————————————一

could

help

tochoose

all

appropriate

operation.(5)Clicical

and

biological

ofinflucencedpmgn0818andmetastasis,significantlyfactors,especiallytumorinvasion

andtnlrlorstagi“gweremetastasisnode

gastriccarcinoma.Tumorinvasion,lymphindependent

prognostic

factors.(6)ExpressionofPTEN,VEGF

and

MMP2

ofVEGFofwithcarcinoma.Expressioncorrelatedgastricprognosissignificantly

and

MMP2

wereindependentprognosticfactors.ExpressionofPTEN,VEGF

serve

andMMP2

couldfairly

asprognosticfactorsingastriccarcinoma

factor/endothelialgrowthGastricNeopla …… 此处隐藏:1810字,全部文档内容请下载后查看。喜欢就下载吧 ……

PTEN、VEGF和MMP2在胃癌组织中的表达及其与胃癌浸润、转移和预后(2).doc 将本文的Word文档下载到电脑,方便复制、编辑、收藏和打印
本文链接:https://www.jiaowen.net/wenku/97771.html(转载请注明文章来源)
Copyright © 2020-2025 教文网 版权所有
声明 :本网站尊重并保护知识产权,根据《信息网络传播权保护条例》,如果我们转载的作品侵犯了您的权利,请在一个月内通知我们,我们会及时删除。
客服QQ:78024566 邮箱:78024566@qq.com
苏ICP备19068818号-2
Top
× 游客快捷下载通道(下载后可以自由复制和排版)
VIP包月下载
特价:29 元/月 原价:99元
低至 0.3 元/份 每月下载150
全站内容免费自由复制
VIP包月下载
特价:29 元/月 原价:99元
低至 0.3 元/份 每月下载150
全站内容免费自由复制
注:下载文档有可能出现无法下载或内容有问题,请联系客服协助您处理。
× 常见问题(客服时间:周一到周五 9:30-18:00)