cancer susceptibility20111118

Cancer Susceptibility

Disease Susceptibility

A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.

Cancer Process

Cancer EpidemiologyRisk FactorsChronic Inflammation Lung

TargetsTobaccoBreast Prostate Colorectal Hematologic

Alcohol Diet Xenobiotics Familial Obesity Hormones Viral Asbestos Ion. Radiation UV Radiation

Stomach Ovarian Pancreas Liver Esophagus Skin H&N Uterine Cervix Bladder-Kidney

Bone

BrainAdapted from ISPO

Cancer EpidemiologyEnvironmentChronic Inflammation TobaccoAlcohol Diet Xenobiotics Familial Obesity Hormones Viral Asbestos Ion. Radiation UV Radiation Brain

HostLung Breast Prostate Colorectal Hematologic Stomach Ovarian

Gene-Environment Interaction

Pancreas Liver Esophagus

Skin H&N Uterine Cervix Bladder-Kidney

Bone

Molecular EpidemiologyBiomarkersMetabolism Lung

HostBreast Prostate Colorectal Hematologic

DNA adductsMutagen sensitivity

PolymorphismsDNA repair Cell cycle Apoptosis

Stomach Ovarian

Gene-Gene Interactions

Pancreas Liver Esophagus

Methylationimprinting Telomerase Angiogenesis Genomic instability Brain

Skin H&N Uterine Cervix Bladder-Kidney

Bone

Gene-EnvironmentEnvironment + -

Genetic +

spontaneous 15%

pure environment 2% Geneenvironment interaction 78%

17%

pure genetic 5%

83%

20%

80%

100%Schulte, 1994

“Genetics loads gun, but Environments trigger”

What is gene

Gene Function

Gene Variations

Gene Variations

Disease Susceptibility

Genetic Testing

Genetic Testing Results

Environmental Factors

Over all Assessment

Thank YouMichael Fu