哈尔滨医科大学八十周年校庆系列学术活动(3)

40. Schneider A, Guan Y, Zhang Y, Magnuson MA, Loftin CD, Langenbach R, Breyer

RM, and Breyer MD: Generation of mice suitable for conditional prostaglandin EP4 receptor deletion. Genesis 2004; 40:7-14

41. Guan Y. Invited Review: PPAR family and renal complications of the metabolic

syndrome. J. Am. Soc. Nephrol. 2004 Nov;15(11):2801-15

42. Zheng F, Chen Q, Plati A-R, Ye S-Q, Berho M, Banerjee A, Potier M, Jaimes EA, Guan

Y, Hao C, Striker LJ, Striker GE. The glomerulosclerosis of aging: Contribution of the proinflammatory mesangial cell phenotype to macrophage infiltration. Am. J. Pathol. 2004; 165:1789-1798;

43. Wu J, Zhang Y, Yang G, Wang N, Zhu Y, Wang X, Davis L, Breyer MD, Guan Y:

Liver X receptor alpha mediates cholesterol efflux in cultured mesangial cells. . Am. J. Physiol. (Renal Physiol.) 2004; 287:F886-F895;

44. Xiong Z, Huang H, LI J, Guan Y, Wang H: Anti-inflammatory effect of PPARg in

cultured human mesangial cells. Renal Failure 2004; 26:497-505;

45. Zeng X-K, Guan Y, Remick D. G. Wang X. Signal pathways underlying

homocysteine-induced production of MCP-1 and IL-8 in cultured human whole blood. Acta Phamacologica Sinica 2005; 26(1):85-91;

46. Wang G, Wei J, Guan Y, Jin N, Mao J, Wang X: PPAR? agonist rosiglitazone reduces

inflammatory response in type II diabetic patients with coronary arterial disease flowing coronary angioplasty. Metabolism 2005; 54(5):590-597.

47. Yang F, Zhang Z, Xin D, Shi C, Wu JP, Guo YL, Guan Y: PPAR? ligands induce cell

cycle arrest and apoptosis in human renal carcinoma cell Lines. Acta Pharmacologica Sinica 2005;26(6):736-761.

48. Guan Y, Hao C, Rao R, Cha DR, Kohan D, Magnuson M, Zhang Y, Breyer MD:

PPAR? regulates systemic fluid volume by activating sodium absorption in the collecting duct._ Nature Medicine 2005 Aug;11(8):861-866;

49. Hebert R, Saito O, Carmosino M, Yang G, Jackson C, Qi Z, Zhang Y, Guan Y, Breyer

M: Characterization of the rabbit PGF2alpha receptor (FP) and its Gi restricted signaling pathway inhibiting water absorption in renal collecting duct. J. Biol. Chem. 280(41):35028-37;

50. Zhan P, Alander C, Kaneko H, Pilbeam CC, Guan Y, Zhang Y, Breyer MD, Raisz LG:

Effect of deletion of the prostaglandin EP4 receptor on stimulation of calcium release from cultured mouse calvariae: Impaired responsiveness in heterozygous. Prostaglandins Other Lipid Mediat. 2005 Dec;78(1-4):19-26.;

51. Xie L, Chang L, Guan Y, Wang X: C-reactive protein augments interleukin-8

secretion in human peripheral blood monocytes. J Cardiovasc Pharmacol. 2005 Nov;46(5):690-6.

52. Zhang Y & Guan Y: PPAR-gamma agonists and diabetic nephropathy. Current Diabetes Reports 2005；5：470-475 (Invited Review).

53. Park WC, Zhang Y, Wu J, Lu W, Fan X, Davis L, Pozzi A, Capdevila J, Zeng F, Breyer

M, Guan Y: PPARalpha agonist improves diabetic parameters and diabetic nephropathy in db/db mice. Kidney Int. 2006 (in press).

54. Zhang Y, Wu J, Yang G, Lu W, Hwang M-T, Davis L, Breyer M, Guan Y: Liver X

receptor (LXR) agonist TO901317 upregulates SCD1 expression in renal proximal straight tubule. Am J Physiol (Renal Physiol) (in press);

55. Park CW, Kim HW, Chung HW, Lim SW, Yang CW, Chang YS, Sugawara A, Guan Y,

Breyer MD: Accelerated Diabetic Nephropathy in Mice Lacking the Peroxisome

Proliferator-Activated Receptor-?. Diabetes (in revision);

56. Nakagawa K, Holla VR, Wei Y, Wang W-H, Wei S, Mei S, Cha DR, Price E Jr, Zent

R, Pozzi A, Breyer MD, Guan Y, Falck JR, Waterman M, Capdevila JH: Salt sensitive hypertension is associated with cytochrome P450 epoxygenase-mediated changes in the activity of the renal epithelial sodium channel. Nature (in revision);

57. Guan Y, Zhang Y, Qi Z, Yang G, Davis L, Wei MF, Fan XF, Breyer R, Breyer MD:

Prostaglandin E2 receptor EP1 is an vasopressor in blood pressure regulation. Cell Metabolism (submitted);

58. Cha DR, Su D., Zhang Y, Fan X, Breyer M, Guan Y: Peroxisome Proliferator

Activated Receptor ? Deficiency Protect From High Fat Diet-Induced Insulin Resistance in Aging Mice. Diabetologia (submitted);

59. Cha DR, Su DM, Han JY, Zhang Y, Fan XF, Breyer MD, Guan Y: PPAR ??? Dual

Agonist Tesaglitazar (AZ242) attenuates Diabetic Nephropathy in db/db Mice. Diabetes (submitted);

60. Zhang Y, Lu W, Fan XF, Shappell SB, Roberts R, Davis L, Guan Y: PPAR? agonists

decrease albuminuria and slow progression of diabetic nephropathy in obese diabetic db/db mice. (in preparation).

61. Zhang Y, Fan XF, Capdevila J, Breyer MD, Guan Y: Activation of a cytochrome p450

arachidonate epoxygenase contributes to normalization of blood pressure produced by the antidiabetic PPAR? ligand troglitazone in SHR rats. (in preparation).

汪南平 教授 博士生导师

专业：生理学

最后学历：医学博士

研究专长：心血管分子生物学与生物工程学 工作单位：北京大学心血管研究所

北京大学医学部生理学与病理生理学系（兼）

联系地址：北京市海淀区学院路38号 北京大学医学部心血管研究所

血管分子生物学与生物工程学研究室 电话：10-82801146

E-mail:npwang@bjmu.edu.cn 学习和工作经历

1983-1986西安医科大学 医学硕士

1986-1988西安医科大学第二临床学院 医师 1989-1990日本北里大学医学部 访问学者 1991-1994北京医科大学 医学博士

1994-1995德国柏林自由大学医学中心 访问学者

1995-1996美国印地安那大学医学院微生物与免疫学系 博士后 1996-2000美国加利福尼亚大学（河滨）生物医学系 博士后

2000-2002美国加利福尼亚大学（河滨）生物医学系 研究助理教授 2003-2005美国加利福尼亚大学（圣地亚哥）生物工程系 研究助理教授 2003- 北京大学医学部心血管研究所 教授 副所长

研究方向代谢性核受体

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